Neurology 2003;60:1183-1185
© 2003 American Academy of Neurology
Brief Communications
Cholinergic denervation in a pure multi-infarct state
Observations on CADASIL
Marsel Mesulam, MD,
Teepu Siddique, MD and
Bruce Cohen, MD
From the Cognitive Neurology and Alzheimer’s Disease Center and the Departments of Neurology and Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago IL.
Address correspondence and reprint requests to Dr. M. Mesulam, 320 E. Superior St., Chicago, IL 60611; e-mail: mmesulam{at}northwestern.edu
Circumstantial evidence suggests that vascular dementia (VaD) may be associated with cholinergic denervation. The specificity of this association has been difficult to assess because many of the patients are elderly and have the additional cholinergic lesions of aging and AD. A patient with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) who died at age 36 showed that pure white matter infarcts, similar to those seen in VaD, can cause cortical cholinergic denervation, but in patterns that vary from those seen in AD.
This article has been cited by other articles:
|
|
|
|
 
N. I. Bohnen, M. L.T.M. Muller, H. Kuwabara, G. M. Constantine, and S. A. Studenski
Age-associated leukoaraiosis and cortical cholinergic deafferentation
Neurology,
April 21, 2009;
72(16):
1411 - 1416.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M L Stromillo, M T Dotti, M Battaglini, M Mortilla, S Bianchi, K Plewnia, L Pantoni, D Inzitari, A Federico, and N De Stefano
Structural and metabolic brain abnormalities in preclinical cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy
J. Neurol. Neurosurg. Psychiatry,
January 1, 2009;
80(1):
41 - 47.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Erkinjuntti, S. Gauthier, R. Bullock, A. Kurz, G. Hammond, S. Schwalen, Y. Zhu, and R. Brashear
Galantamine treatment in Alzheimer's disease with cerebrovascular disease: responder analyses from a randomized, controlled trial (GAL-INT-6)
J Psychopharmacol,
September 1, 2008;
22(7):
761 - 768.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. H. Taylor and G. A. Doody
CADASIL: a guide to a comparatively unrecognised condition in psychiatry
Adv. Psychiatr. Treat.,
September 1, 2008;
14(5):
350 - 357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. Auchus, H. R. Brashear, S. Salloway, A. D. Korczyn, P. P. De Deyn, C. Gassmann-Mayer, and For the GAL-INT-26 Study Group
Galantamine treatment of vascular dementia: A randomized trial
Neurology,
July 31, 2007;
69(5):
448 - 458.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Behl, C. Bocti, R. H. Swartz, F. Gao, D. J. Sahlas, K. L. Lanctot, D. L. Streiner, and S. E. Black
Strategic Subcortical Hyperintensities in Cholinergic Pathways and Executive Function Decline in Treated Alzheimer Patients
Arch Neurol,
February 1, 2007;
64(2):
266 - 272.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Keverne, W. C. R. Low, I. Ziabreva, J. A. Court, A. E. Oakley, and R. N. Kalaria
Cholinergic Neuronal Deficits in CADASIL
Stroke,
January 1, 2007;
38(1):
188 - 191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Berthier, C. Green, C. Higueras, I. Fernandez, J. Hinojosa, and M. C. Martin
A randomized, placebo-controlled study of donepezil in poststroke aphasia.
Neurology,
November 14, 2006;
67(9):
1687 - 1689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Viswanathan, F. Gray, M.-G. Bousser, M. Baudrimont, and H. Chabriat
Cortical Neuronal Apoptosis in CADASIL
Stroke,
November 1, 2006;
37(11):
2690 - 2695.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Charlton, R. G. Morris, A. Nitkunan, and H. S. Markus
The cognitive profiles of CADASIL and sporadic small vessel disease
Neurology,
May 23, 2006;
66(10):
1523 - 1526.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F Buffon, R Porcher, K Hernandez, A Kurtz, S Pointeau, K Vahedi, M-G Bousser, and H Chabriat
Cognitive profile in CADASIL
J. Neurol. Neurosurg. Psychiatry,
February 1, 2006;
77(2):
175 - 180.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rufa, M. T. Dotti, M. Franchi, M. L. Stromillo, G. Cevenini, S. Bianchi, N. De Stefano, and A. Federico
Systemic Blood Pressure Profile in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Stroke,
December 1, 2005;
36(12):
2554 - 2558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. O'Sullivan, T. R. Barrick, R. G. Morris, C. A. Clark, and H. S. Markus
Damage within a network of white matter regions underlies executive dysfunction in CADASIL
Neurology,
November 22, 2005;
65(10):
1584 - 1590.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Peters, C. Opherk, A. Danek, C. Ballard, J. Herzog, and M. Dichgans
The Pattern of Cognitive Performance in CADASIL: A Monogenic Condition Leading to Subcortical Ischemic Vascular Dementia
Am J Psychiatry,
November 1, 2005;
162(11):
2078 - 2085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Bocti, R. H. Swartz, F.-Q. Gao, D. J. Sahlas, P. Behl, and S. E. Black
A New Visual Rating Scale to Assess Strategic White Matter Hyperintensities Within Cholinergic Pathways in Dementia
Stroke,
October 1, 2005;
36(10):
2126 - 2131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tomimoto, R. Ohtani, M. Ihara, and E.K. Perry
Absence of cholinergic deficits in "pure" vascular dementia
Neurology,
July 12, 2005;
65(1):
179 - 179.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Perry, I. Ziabreva, R. Perry, D. Aarsland, and C. Ballard
Absence of cholinergic deficits in "pure" vascular dementia
Neurology,
January 11, 2005;
64(1):
132 - 133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Erkinjuntti, G. Roman, S. Gauthier, H. Feldman, and K. Rockwood
Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment
Stroke,
April 1, 2004;
35(4):
1010 - 1017.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
