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Neurology 2003;60:1189-1191
© 2003 American Academy of Neurology
Brief Communications

Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson’s disease

J. M. van der Walt, PhD, E.R. Martin, PhD, W. K. Scott, PhD, F. Zhang, PhD, M.A. Nance, MD, R. L. Watts, MD, J. P. Hubble, MD, J. L. Haines, PhD, W. C. Koller, MD, K. Lyons, PhD, R. Pahwa, MD, M. B. Stern, MD, A. Colcher, MD, B. C. Hiner, MD, J. Jankovic, MD, W. G. Ondo, MD, F. H. Allen, Jr., MD, C. G. Goetz, MD, G. W. Small, MD, F. Mastaglia, MD, A. D. Roses, MD, J. M. Stajich, PA-C, M.W. Booze, BS, K. Fujiwara, BS, R. A. Gibson, PhD, L. T. Middleton, MD, B. L. Scott, MD, M. A. Pericak-Vance, PhD and J. M. Vance, PhD MD

From the Department of Medicine and Center for Human Genetics (Drs. Van der Walt, Martin, W.K. Scott, Zhang, B.L. Scott, Pericak-Vance, and Vance; J.M. Stajich, M.W. Booze, and K. Fujiwara), Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC; Struthers Parkinson Center (Dr. Nance), Golden Valley, MN; Department of Neurology (Dr. Watts), Emory University School of Medicine, Atlanta, GA; Ohio State University, Columbus, OH (Dr. Hubble); Program in Human Genetics, Vanderbilt University Medical Center, Nashville, TN (Dr. Haines); Department of Neurology, University of Miami School of Medicine, FL (Drs. Koller and Lyons); University of Kansas Medical Center, Kansas City (Dr. Pahwa); University of Pennsylvania Health System, Philadelphia (Drs. Stern and Colcher); Marshfield Clinic, WI (Dr. Hiner); Baylor College of Medicine, Houston, TX (Drs. Jankovic and Ondo); Carolina Neurologic Clinic, Charlotte, NC (Dr. Allen); Department of Neurological Sciences, Rush-Presbyterian-St. Luke’s Hospital, Chicago, IL (Dr. Goetz); Departments of Psychiatry & Biobehavioral Science and Neurology, University of California, Los Angeles (Dr. Small); Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth (Dr. Mastaglia); GlaxoSmithKline Research and Development, Research Triangle Park, NC (Dr. Roses) and Greenford, Middlesex, UK (Drs. Gibson and Middleton).

Address correspondence and reprint requests to Dr. Jeffery M. Vance, Center for Human Genetics, Box 2903, Duke University Medical Center, Durham, NC 27710; e-mail: jeff.vance{at}duke.edu

Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).






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