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Neurology 2003;60:1192-1194
© 2003 American Academy of Neurology
Brief Communications

Progressive affective aprosodia and prosoplegia

Georges A. Ghacibeh, MD and Kenneth M. Heilman, MD

From the Department of Neurology, University of Florida College of Medicine and the Neurology Service, North Florida–South Georgia Veterans Affairs Medical Center, Gainesville.

Address correspondence and reprint requests to Dr. Georges A. Ghacibeh, Department of Neurology, University of Florida College of Medicine and the Neurology Service, North Florida–South Georgia Veterans Affairs Medical Center, PO Box 100236, Gainseville, FL 32610; e-mail: ghacig{at}neurology.ufl.edu

The right frontal lobe is important for the expression of emotional prosody, emotional faces, and automatic speech. The authors describe a woman who presented with progressive expressive affective aprosodia, affective prosoplegia, amusia, and loss of automatic speech but with an intact ability to understand emotional prosody and faces as well as express and understand syntactic prosody. MRI showed predominant right frontal cortical atrophy. The authors suggest that this patient has a form of frontotemporal dementia, analogous to primary progressive aphasia but disrupting right frontal lobe–mediated functions.




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