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Neurology 2003;60:1194-1196
© 2003 American Academy of Neurology
Brief Communications

MRS in relation to hippocampal volume in the oldest old

David C. Spencer, MD, Tracy Zitzelberger, BA, Daniel Spielman, PhD and Jeffrey Kaye, MD

From the Oregon Health & Science University (Drs. Spencer and Kaye, and T. Zitzelberger), Portland, OR; and Stanford University Lucas Center for Magnetic Resonance Imaging and Spectroscopy (Dr. Spielman), CA.

Address correspondence and reprint requests to Dr. David C. Spencer, Oregon Health & Science University, Department of Neurology, 3181 SW Sam Jackson Park Rd., CDW-3, Portland, OR 97201; e-mail: spencerd{at}ohsu.edu

The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. MRS was used to study medial temporal and parietal regions in 60 cognitively healthy subjects older than 85 years. Subjects with small hippocampal volumes, a putative risk factor for dementia, had significantly lower NAA/mI in parietal and temporal lobes compared with other subjects. Neuropsychological tests and APOE genotype did not correlate with MRS ratios. MRS measures are candidate biomarkers for dementia risk.




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M. E. Zimmerman, J. W. Pan, H. P. Hetherington, M. J. Katz, J. Verghese, H. Buschke, C. A. Derby, and R. B. Lipton
Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults
Neurology, April 29, 2008; 70(18): 1594 - 1600.
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