HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pagan, F. L. Articles by Hallett, M. Search for Related Content PubMed PubMed Citation Articles by Pagan, F. L. Articles by Hallett, M. Related Collections MRS Tremor

Evaluation of essential tremor with multi-voxel magnetic resonance spectroscopy

From the Medical Neurology Branch (Drs. Pagan and Hallett) and Biostatistics Branch (Dr. Dambrosia), National Institutes of Health, National Institute of Neurological Disorders and Stroke; Diagnostic Radiology Department (Dr. Butman), Warren G. Magnuson Clinical Center, Bethesda, MD.

Address correspondence and reprint requests to Dr. Mark Hallett, NIH, NINDS, HMCS, Building 10, Room 5N226, 10 Center Drive, MSC1428, Bethesda, MD 20892-1428; e-mail: hallettm{at}ninds.nih.gov

The pathologic substrate of essential tremor (ET) remains unknown. The authors studied 10 patients with ET and 10 volunteers using a multislice MR spectroscopy imaging sequence. Left and right cerebellar hemisphere NAA/CR and NAA/Cho ratios were significantly smaller in the ET patients than healthy subjects. The authors’ data suggest that the decreased NAA/Cr and NAA/Cho ratios within the cerebellum may represent an abnormality in neuronal function.

This article has been cited by other articles:

				D.H. Shin, B.S. Han, H.S. Kim, and P.H. Lee Diffusion Tensor Imaging in Patients With Essential Tremor AJNR Am. J. Neuroradiol., January 1, 2008; 29(1): 151 - 153. [Abstract] [Full Text] [PDF]

				E. D. Louis, P. L. Faust, J.-P. G. Vonsattel, L. S. Honig, A. Rajput, C. A. Robinson, A. Rajput, R. Pahwa, K. E. Lyons, G.W. Ross, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls Brain, December 1, 2007; 130(12): 3297 - 3307. [Abstract] [Full Text] [PDF]

				E. D. Louis, W. Zheng, X. Mao, and D. C. Shungu Blood harmane is correlated with cerebellar metabolism in essential tremor: A pilot study Neurology, August 7, 2007; 69(6): 515 - 520. [Abstract] [Full Text] [PDF]

				J. Raethjen, R. B. Govindan, F. Kopper, M. Muthuraman, and G. Deuschl Cortical Involvement in the Generation of Essential Tremor J Neurophysiol, May 1, 2007; 97(5): 3219 - 3228. [Abstract] [Full Text] [PDF]

				C. Daniels, M. Peller, S. Wolff, K. Alfke, K. Witt, C. Gaser, O. Jansen, H. R. Siebner, and G. Deuschl Voxel-based morphometry shows no decreases in cerebellar gray matter volume in essential tremor Neurology, October 24, 2006; 67(8): 1452 - 1456. [Abstract] [Full Text] [PDF]

				S. Klebe, H. Stolze, K. Grensing, J. Volkmann, R. Wenzelburger, and G. Deuschl Influence of alcohol on gait in patients with essential tremor Neurology, July 12, 2005; 65(1): 96 - 101. [Abstract] [Full Text] [PDF]

				J. J. Higgins, R. Q. Lombardi, J. Pucilowska, J. Jankovic, E. K. Tan, and J. P. Rooney A variant in the HS1-BP3 gene is associated with familial essential tremor Neurology, February 8, 2005; 64(3): 417 - 421. [Abstract] [Full Text] [PDF]

				D. A. Rottenberg Why Rome trembles: "E avanti a lui tremava tutta Roma!" (Tosca, Act II) Neurology, April 22, 2003; 60(8): 1232 - 1233. [Full Text] [PDF]