Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meyer, T.
Right arrow Articles by Prudlo, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meyer, T.
Right arrow Articles by Prudlo, J.
Related Collections
Right arrow All Neuromuscular Disease
Right arrow Anterior nerve cell disease
Right arrow Amyotrophic lateral sclerosis
Right arrow All Genetics
Right arrow Genetic linkage

Neurology 2003;60:1348-1350
© 2003 American Academy of Neurology
Brief Communications

High rate of constitutional chromosomal rearrangements in apparently sporadic ALS

T. Meyer, MD, B. Alber, MD, K. Roemer, PhD, T. Martin, MD, V.M. Kalscheuer, PhD, E. Göttert, PhD, K.D. Zang, MD, A.C. Ludolph, MD, H.-H. Ropers, MD and J. Prudlo, MD

From the Department of Neurology (Dr. Meyer), Charité University Hospital, Humboldt University, Berlin; Department of Neurology (Drs. Alber and Ludolph), University of Ulm; Departments of Virology (Dr. Roemer), Human Genetics (Drs. Martin, Göttert, and Zang), and Neurology (Dr. Prudlo), University Hospital, Homburg; and Max Planck Institute for Molecular Genetics (Drs. Kalscheuer and Ropers), Berlin, Germany.

Address correspondence and reprint requests to Dr. Thomas Meyer, Universitätsklinikum Charité, Neurologische Klinik, Augustenburger Platz 1, 13353 Berlin, Germany; e-mail: thomas.meyer{at}charite.de

Of 85 patients with ALS, the authors identified 3 patients with balanced translocations and 2 patients with pericentric inversions, all affecting distinct chromosomal loci. The high rate of constitutional aberrations (5.9%) suggests that ALS is, in part, associated with recombination-based rearrangements of genomic sequences.




This article has been cited by other articles:


Home page
 NeurologyHome page
C. W. Noonan, M. C. White, D. Thurman, and L.-Y. Wong
Temporal and geographic variation in United States motor neuron disease mortality, 1969-1998
Neurology, April 12, 2005; 64(7): 1215 - 1221.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by AAN Enterprises, Inc.