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Comparison of Alzheimer’s disease risk factors in white and African American families

From the Departments of Medicine, Psychiatry, and Neurology (Dr. Bachman), Medical University of South Carolina, Charleston; and Departments of Neurology (Drs. Green and Farrer), Medicine (Genetics Program) (Drs. Green and Farrer, K.S. Benke), and Genetics and Genomics (Dr. Farrer), Boston University School of Medicine, and Departments of Epidemiology (Drs. Green and Farrer) and Biostatistics (Drs. Cupples and Farrer), Boston University School of Public Health, MA.

Address correspondence and reprint requests to Dr. Lindsay A. Farrer, Genetics Program, Boston University School of Medicine, 715 Albany St., Boston, MA 02118; e-mail: farrer{at}bu.edu

The associations between alcohol, smoking, and head injury and the risk of AD in 443 African American and 2,336 white participants in the MIRAGE Study were evaluated. Alcohol had a modest protective effect in whites (odds ratio [OR] = 0.82, 95% CI = 0.68 to 0.99), with a similar trend in African Americans (OR = 0.88, 95% CI = 0.54 to 1.4). Head trauma increased the risk of AD in whites (OR = 2.3, 95% CI = 1.8 to 3.0) and African Americans (OR = 2.9, 95% CI = 1.2 to 7.0). Smoking was not associated with AD risk in whites (OR = 0.88, 95% CI = 0.73 to 1.1) or African Americans (OR = 1.0, 95% CI = 0.69 to 1.5). These risks were similar across subsets stratified by the presence or absence of the APOE 4 allele.

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