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Neurology 2003;60:1374-1377
© 2003 American Academy of Neurology
Brief Communications

Mild cognitive impairment

Can FDG-PET predict who is to rapidly convert to Alzheimer’s disease?

G. Chételat, PhD, B. Desgranges, PhD, V. de la Sayette, MD, F. Viader, MD, F. Eustache, PhD and J.-C. Baron, MD

From INSERM EO 218 (Drs. Chételat, Desgranges, de la Sayette, Viader, and Eustache), University of Caen, Cyceron PET Center, France; EPHE (Dr. Eustache), CNRS UMR 8581, University René Descartes, Paris, France; Service de Neurologie Vastel, CHU de Caen (Dr. Viader); and Department of Neurology (Dr. Baron), University of Cambridge, UK.

Address correspondence and reprint requests to Prof. Jean-Claude Baron, University of Cambridge, Dept. of Neurology, Addenbrooke’s Hospital, Box 83, Cambridge CB2 2QQ, UK; e-mail: JCB54{at}CAM.AC.UK

Patients with mild cognitive impairment (MCI) were assessed, and a metabolic profile associated with conversion to AD at 18-month follow-up was sought. As compared with nonconverters (n = 10), converters (n = 7) had lower fluorodeoxyglucose uptake in the right temporoparietal cortex (p = 0.02, corrected for cluster size), without individual overlap. Awaiting replication in an independent sample, these findings suggest that among patients with MCI, fluorodeoxyglucose PET may accurately identify rapid converters.




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