HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sander, H. W. Articles by Latov, N. Search for Related Content PubMed PubMed Citation Articles by Sander, H. W. Articles by Latov, N.

Neurology supplements are not peer-reviewed. Information contained in Neurology supplements represent the opinions of the authors and are not endorsed by nor do they reflect the views of the American Academy of Neurology, Editor-in-Chief, or Associate Editors of Neurology.

Research criteria for defining patients with CIDP

From the Peripheral Neuropathy Center, Department of Neurology, Weill Medical College of Cornell University, New York, NY (Drs. Sander and Latov) and Department of Neurology, New York University School of Medicine, New York, NY (Dr. Sander).

Address correspondence and reprint requests to Dr. Howard W. Sander, Peripheral Neuropathy Center, 635 Madison Avenue, Suite 400, New York, NY 10022; e-mail: hws2001{at}med.cornell.edu

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is one of several chronic acquired demyelinating neuropathies that are considered to be autoimmune diseases. The prevalence of these illnesses may be underestimated because of limitations in clinical, serologic, and electrophysiologic diagnostic criteria. An Ad Hoc Subcommittee of the American Academy of Neurology (AAN) proposed a set of diagnostic criteria for CIDP to be used for research purposes, and several other criteria followed. Of these, the AAN electrophysiologic criteria are the most restrictive and fit only a subset of patients with CIDP. Other criteria, including the Inflammatory Neuropathy Cause and Treatment (INCAT) clinical and electrophysiologic criteria and the Nicolas or Thaisetthawatkul electrophysiologic criteria, are more sensitive and can therefore identify a broader range of patients with CIDP for clinical trials. Regardless of which criteria are chosen for use in clinical trials, patients who fall outside of these criteria may also have CIDP and may benefit from treatment. Unfortunately, because of the lack of clarity with regard to diagnostic criteria for CIDP, many patients remain untreated. In addition, certain CIDP variants may also respond to treatment. These include sensory CIDP, multifocal motor neuropathy (MMN) with or without conduction block, multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy, distal acquired demyelinating sensory (DADS) neuropathy, and multifocal acquired sensory and motor (MASAM) neuropathy. Therefore, although patients may not meet the diagnostic criteria for inclusion in clinical trials of CIDP, they may still benefit from current and future treatments used in CIDP.

This article has been cited by other articles:

				M Iijima, H Koike, N Hattori, A Tamakoshi, M Katsuno, F Tanaka, M Yamamoto, K Arimura, G Sobue, and the Refractory Peripheral Neuropathy Study Group o Prevalence and incidence rates of chronic inflammatory demyelinating polyneuropathy in the Japanese population J. Neurol. Neurosurg. Psychiatry, September 1, 2008; 79(9): 1040 - 1043. [Abstract] [Full Text] [PDF]

				B. Tackenberg, J. D. Lunemann, A. Steinbrecher, E. Rothenfusser-Korber, M. Sailer, W. Bruck, S. Schock, R. Zschenderlein, F. Zipp, and N. Sommer Classifications and treatment responses in chronic immune-mediated demyelinating polyneuropathy Neurology, May 8, 2007; 68(19): 1622 - 1629. [Abstract] [Full Text] [PDF]

				G. Andreisek, D. W. Crook, D. Burg, B. Marincek, and D. Weishaupt Peripheral Neuropathies of the Median, Radial, and Ulnar Nerves: MR Imaging Features RadioGraphics, September 1, 2006; 26(5): 1267 - 1287. [Abstract] [Full Text] [PDF]

				C. Sommer, S. Koch, M. Lammens, A. Gabreels-Festen, G. Stoll, and K. V. Toyka Macrophage clustering as a diagnostic marker in sural nerve biopsies of patients with CIDP Neurology, December 27, 2005; 65(12): 1924 - 1929. [Abstract] [Full Text] [PDF]

				C. Richez, P. Blanco, A. Lagueny, T. Schaeverbeke, and J. Dehais Neuropathy resembling CIDP in patients receiving tumor necrosis factor-{alpha} blockers Neurology, April 26, 2005; 64(8): 1468 - 1470. [Abstract] [Full Text] [PDF]

				H. Koller, B. C. Kieseier, S. Jander, and H.-P. Hartung Chronic Inflammatory Demyelinating Polyneuropathy N. Engl. J. Med., March 31, 2005; 352(13): 1343 - 1356. [Full Text] [PDF]

				P. Kelkar Forme Fruste Manifestations of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Arch Neurol, June 1, 2004; 61(6): 984 - 984. [Full Text]