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Neurology 2003;60:1529-1532
© 2003 American Academy of Neurology
Brief Communications

Neurophysiological findings in SPG4 patients differ from other types of spastic paraplegia

T. Schulte, MD, B. Miterski, MD, C. Börnke, MD, H. Przuntek, MD, J. T. Epplen, MD and L. Schöls, MD

From the Department of Neurology (Drs. Schulte, Börnke, Przuntek, and Schöls), St. Josef Hospital, and Department of Human Genetics (Drs. Miterski and Epplen), Ruhr University, Bochum, Germany.

Address correspondence and reprint requests to Prof. Dr. Ludger Schöls, Department of Neurology, St. Josef Hospital, Ruhr-University Bochum, Gudrunstr. 56, D-44791 Bochum, Germany; e-mail: Ludger.Schoels{at}ruhr-uni-bochum.de

The authors examined 12 families with autosomal dominant hereditary spastic paraplegia for phenotypic characteristics predicting the underlying genotype. They found no clinical differences between patients with or without mutations in the spastin gene (SPG4). Motor evoked potentials and nerve conduction studies were almost normal in those with SPG4. In contrast, non-SPG4 families had prolonged central motor conduction times or marked peripheral neuropathy, or both.




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Correspondence:

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Neurophysiological findings in SPG4 are variable, dependent on the type of spastin mutation
Tohru Matsuura, et al.
Neurology Online, 17 Dec 2003 [Full text]

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