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Neurology 2003;61:104-107
© 2003 American Academy of Neurology
Brief Communications

Factors predictive of corticosteroid psychosis in patients with systemic lupus erythematosus

Shuk Yi Chau, MRCP MBBS and Chi Chiu Mok, MD MRCP

From the Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong SAR, China.

Address correspondence and reprint requests to Dr. Chi Chiu Mok, Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong; e-mail: ccmok{at}netvigator.com

Corticosteroid-induced psychosis occurred in 5% of a prospective cohort of 92 patients with systemic lupus erythematosus (SLE). Psychosis was unpredictable by the routes and dosage of corticosteroid used. Factors predictive of psychosis were low serum levels of albumin, complement, and creatinine; history of anxiety disorders; and a family history of psychiatric illnesses. After multivariate adjustment, only hypoalbuminemia remained significant.




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