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Neurology 2003;61:108-110
© 2003 American Academy of Neurology
Brief Communications

Neuropsychiatric lupus syndromes

Relationship with antiphospholipid antibodies

Antonella Afeltra, MD, Pierluigi Garzia, MD, Anna Paola Mitterhofer, MD, Marta Vadacca, MD, Sara Galluzzo, MD, Flavia Del Porto, MD, Licia Finamore, MD, Stefano Pascucci, MD, Marina Gasparini, MD, Bruno Laganà, MD, Domenico Caccavo, MD, Giovanni Maria Ferri, MD, Antonio Amoroso, MD and Ada Francia, MD

From the University "Campus Bio-Medico" (Drs. Afeltra and Vadacca), Rome, Italy; Departments of Clinical Medicine (Drs. Garzia, Mitterhofer, Galluzzo, Del Porto, Laganà, Ferri, and Amoroso) and Neurological Sciences (Drs. Finamore, Pascucci, Gasparini, and Francia), University "La Sapienza," Rome, Italy; and Department of Clinical Medicine, Immunology, and Infectious Diseases (Dr. Caccavo), University of Bari, Italy.

Address correspondence and reprint requests to Prof. A. Afeltra, University "Campus Bio-Medico," Via E. Longoni 83, 00155 Rome, Italy; e-mail: a.afeltra{at}unicampus.it

The authors assessed the prevalence of neuropsychiatric manifestations occurring in patients with systemic lupus erythematosus (NPSLE), according to the American College of Rheumatology standardized definitions for NPSLE, and evaluated the relationship between NPSLE and antiphospholipid antibodies. Sixty-one consecutive SLE patients were studied. Neuropsychiatric manifestations consistent with the diagnosis of NPSLE occurred in 44 (72%). Patients with NPSLE showed significantly higher levels of anticardiolipin antibodies.




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