| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Health Sciences Research (Drs. Elbaz, Schaid, and Rocca, S.K. McDonnell and K.J. Strain) and Neurology (Drs. Maraganore, Bower, Ahlskog, and Rocca), Mayo Clinic and Mayo Foundation, Rochester, MN.
Address correspondence and reprint requests to Dr. Walter A. Rocca, Department of Health Sciences Research, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905; e-mail: rocca{at}mayo.edu
Objective: To study the validity of information provided by case and control subjects (or their proxies) about PD among their first-degree relatives.
Methods: Secondary cases of PD were assessed both through a single informant (family history method) and through the study of each relative (family study method). The family study method was considered as the standard for comparison, and the sensitivity and specificity of the family history method were studied.
Results: A total of 133 population-based case subjects and their 655 relatives were recruited, and 119 population-based control subjects and their 511 relatives. Sensitivity was 68% (95% CI = 47 to 85) for cases and 45% (95% CI = 17 to 77) for controls. Specificity was 99% (95% CI = 98 to 99) for cases and 100% (95% CI = 99 to 100) for controls. The odds ratio (OR) for family history of PD was 4.34 (95% CI = 1.63 to 11.58, p = 0.003) using the family history method and 1.86 (95% CI = 0.78 to 4.44, p = 0.16) using the family study method. The former significant OR more than doubled the latter not significant OR (relative bias = 133%). Bias was more pronounced for proxy interviews and for women informants, and when the relatives were siblings, were living, and were examined or had medical record documentation.
Conclusions: Case subjects with PD (or their proxies) are more aware of PD among their first-degree relatives than control subjects (or their proxies); however, they overreport PD in relatives who are not affected. This causes a substantial family information bias.
This article has been cited by other articles:
|
|
 |
|
  I. D. Bezemer, F. J. M. van der Meer, J. C. J. Eikenboom, F. R. Rosendaal, and C. J. M. Doggen The Value of Family History as a Risk Indicator for Venous Thrombosis Arch Intern Med, March 23, 2009; 169(6): 610 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Rogalski, N. Johnson, S. Weintraub, and M. Mesulam Increased Frequency of Learning Disability in Patients With Primary Progressive Aphasia and Their First-Degree Relatives Arch Neurol, February 1, 2008; 65(2): 244 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Arabia, B. R. Grossardt, Y. E. Geda, J. M. Carlin, J. H. Bower, J. E. Ahlskog, D. M. Maraganore, and W. A. Rocca Increased Risk of Depressive and Anxiety Disorders in Relatives of Patients With Parkinson Disease Arch Gen Psychiatry, December 1, 2007; 64(12): 1385 - 1392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F D Dick, G De Palma, A Ahmadi, N W Scott, G J Prescott, J Bennett, S Semple, S Dick, C Counsell, P Mozzoni, et al. Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study Occup. Environ. Med., October 1, 2007; 64(10): 666 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Rocca, J. H. Bower, J. E. Ahlskog, A. Elbaz, B. R. Grossardt, S. K. McDonnell, D. J. Schaid, and D. M. Maraganore Risk of Cognitive Impairment or Dementia in Relatives of Patients With Parkinson Disease Arch Neurol, October 1, 2007; 64(10): 1458 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. DeKosky and K. Marek Looking Backward to Move Forward: Early Detection of Neurodegenerative Disorders Science, October 31, 2003; 302(5646): 830 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Tanner PD or not PD?: That is the question Neurology, July 8, 2003; 61(1): 5 - 6. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
