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Neurology 2003;61:111-114
© 2003 American Academy of Neurology
Brief Communications

Low dose aspirin after ischemic stroke associated with antiphospholipid syndrome

R.H.W.M. Derksen, MD PhD, P.G. de Groot, PhD and L.J. Kappelle, MD PhD

From the Department of Rheumatology and Clinical Immunology (Dr. Derksen), Thrombosis and Hemostasis Laboratory (Dr. de Groot), and Department of Neurology and Rudolf Magnus Institution of Neuroscience (Dr. Kappelle), University Medical Center, Utrecht, the Netherlands.

Address correspondence and reprint requests to Dr. Ronald H.W.M. Derksen, Department of Rheumatology and Clinical Immunology (F02.127), University Medical Center, PO Box 85500, 3508 GA Utrecht, The Netherlands; e-mail: r.h.w.m.derksen{at}digd.azu.nl

The authors describe course and outcome of eight patients with ischemic stroke as the first thrombotic manifestation of antiphospholipid syndrome who received low-dose aspirin as prophylactic treatment. During 8.9 years of follow-up, two patients had a recurrent stroke. Recurrent stroke rate per 100 patient-years on aspirin was 3.5 (95% CI 0.4 to 12.5).




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