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Neurology 2003;61:99-101
© 2003 American Academy of Neurology
Brief Communications

Gaucher’s disease with Parkinson’s disease

Clinical and pathological aspects

B. Bembi, MD, S. Zambito Marsala, MD, E. Sidransky, MD, PhD, G. Ciana, MD, M. Carrozzi, MD, M. Zorzon, MD, C. Martini, MD, M. Gioulis, MD, M.G. Pittis, SD, PhD and L. Capus, MD

From Unità Operativa Dipartimentale di Malattie Metaboliche (Drs. Bembi, Ciana, Martini, and Pittis), Unità Operativa di Neuropsichiatria Infantile (Dr. Carrozzi), I.R.C.C.S. Burlo Garofolo, Trieste; Dipartimento di Medicina Clinica e Neurologia (Drs. Zambito Marsala, Zorzon, Gioulis, and Capus), Università degli Studi di Trieste, Italy; and Clinical Neuroscience Branch NIMH (Dr. Sidransky), Bethesda, MD.

Address correspondence and reprint requests to Dr. Bruno Bembi, Unità Operativa Dipartimentale di Malattie Metaboliche, Istituto di Ricerca e Cura a Crattere Scientifico "Burlo Garofolo," via dell’Istria 65/1, 34137 Trieste, Italy; e-mail: bembi{at}burlo.trieste.it

The association between type 1 Gaucher disease and PD has been reported in the literature. The clinical picture is characterized by the predominance of bilateral akinetic-rigid signs and poor response to levodopa therapy. The authors describe four patients (two siblings) with type 1 Gaucher disease presenting with the following signs of typical PD: asymmetric onset of rigidity, resting tremor, bradykinesia, and a favorable response to Parkinson therapies.




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