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NEUROLOGY 2003;61:1418-1420
© 2003 American Academy of Neurology
Brief Communications

The effects of pramipexole in REM sleep behavior disorder

M.L. Fantini, MD, MSc, J.-F. Gagnon, MPs, D. Filipini, MD and J. Montplaisir, MD, PhD

From the Centre d’étude du sommeil et des rythmes biologiques (Drs. Fantini, Filipini, and Montplaisir, J.-F. Gagnon), Hôpital du Sacré-Coeur, Montréal, Canada; Département de Psychiatrie (Drs. Fantini and Montplaisir), Université de Montréal, Canada; and Centre de Neurosciences de la Cognition (J.-F. Gagnon), UQAM, Canada.

Address correspondence and reprint requests to Dr. Jacques Montplaisir, Centre d’étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Coeur de Montréal, 5400 boulevard Gouin Ouest, Montréal, Québec, Canada H4J 1C5; e-mail: j-montplaisir{at}crhsc.umontreal.ca

The authors evaluated the effects of pramipexole, a dopaminergic D2-D3 receptor agonist, on eight patients with idiopathic REM sleep behavior disorder. Five patients reported a sustained reduction in the frequency or intensity of sleep motor behaviors, which was confirmed by video recording, although no change was observed for the percentage of phasic EMG activity during REM sleep. Surprisingly, a decrease in the percentage of time spent with REM sleep muscle atonia was observed with treatment. The treatment did not modify the indexes of periodic leg movements.

Received March 26, 2003. Accepted in final form August 5, 2003.

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