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NEUROLOGY 2003;61:1426-1429
© 2003 American Academy of Neurology
Brief Communications

CSF hypocretin-1 levels in restless legs syndrome

K. Stiasny-Kolster, MD, E. Mignot, MD, PhD, L. Ling, MD, PhD, J.C. Möller, MD, W. Cassel, MSc and W.H. Oertel, MD

From the Departments of Neurology (Drs. Stiasny-Kolster, Möller, and Oertel) and Internal Medicine (W. Cassel), Philipps-University Marburg, Germany; and Stanford Center for Narcolepsy Research (Drs. Mignot and Ling), Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, CA.

Address correspondence and reprint requests to Dr. Karin Stiasny-Kolster, Department of Neurology, Center of Nervous Diseases, Rudolf-Bultmann-Strasse 8, D-35033 Marburg, Germany; e-mail: stiasny{at}staff.uni-marburg.de

CSF hypocretin-1 levels at 6 PM did not significantly differ between patients with restless legs syndrome (RLS) and control subjects as measured by direct radioimmunoassay and after acid extraction. The authors did not observe significant differences between early onset and late onset RLS. Hypocretin-1 levels did not correlate with RLS severity or polysomnographic measures. These results contrast with previous findings reporting significantly increased CSF hypocretin-1 in the late evening and mostly in early onset RLS.

Received March 10, 2003. Accepted in final form July 26, 2003.






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