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Comparison of PCR-amplified JC virus control region sequences from multiple brain regions in PML

From the Department of Pediatrics (Drs. Yasuda, H. Yabe, Inoue, Shimizu, M. Yabe, and Kato), Tokai University School of Medicine, Kanagawa, and Laboratory of Viral Infection (Dr. Yogo), Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan.

Address correspondence and reprint requests to Dr. Y. Yasuda, Department of Pediatrics, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259-1193, Japan; e-mail: yyasuda{at}cameo.plala.or.jp

The authors report a 14-year-old boy with Wiskott–Aldrich syndrome complicated by progressive multifocal leukoencephalopathy after allogeneic bone marrow transplantation. Several therapeutic approaches were attempted, but there was no response. The patient died 2 months after the onset of neurologic symptoms. We detected three distinct, rearranged regions of JC virus in the cerebellum, occipital lobe, and brainstem. These findings suggest that the brain lesions had three independent origins.

Received January 21, 2003. Accepted in final form August 4, 2003.