HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Klein, M. Articles by Heimans, J.J. Search for Related Content PubMed PubMed Citation Articles by Klein, M. Articles by Heimans, J.J. Related Collections All Oncology Primary brain tumor Assessment of cognitive disorders/dementia

The prognostic value of cognitive functioning in the survival of patients with high-grade glioma

From the Departments of Medical Psychology (Drs. Klein and van der Ploeg), Neurology (Drs. Postma and Heimans), and Neurosurgery (Dr. Vandertop), VU University Medical Center, Amsterdam; Department of Neurology (Dr. Taphoorn), University Medical Center Utrecht; and Division of Psychosocial Research & Epidemiology (Drs. Aaronson and Muller), The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Address correspondence and reprint requests to Dr. M. Klein, VU University Medical Center, Department of Medical Psychology, Van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands; e-mail: m.klein{at}vumc.nl

The authors studied cognitive functioning as a potential predictor of survival in 68 newly diagnosed patients with high-grade glioma. In a combined Cox proportional hazards model, the influence of tumor, treatment, and patient characteristics, including cognitive functioning, was studied. Older age and higher tumor grade were associated with poorer survival. Although cognitive impairment was not found to be an independent prognostic factor for the entire sample, it was associated with significantly poorer survival among older patients with World Health Organization grade IV gliomas. Assessment of cognitive functioning in these patients may improve clinical decision making and thus quality of treatment.

Received June 12, 2003. Accepted in final form August 20, 2003.

This article has been cited by other articles:

				I. Bosma, L. Douw, F. Bartolomei, J. J. Heimans, B. W. van Dijk, T. J. Postma, C. J. Stam, J. C. Reijneveld, and M. Klein Synchronized brain activity and neurocognitive function in patients with low-grade glioma: A magnetoencephalography study Neuro-oncol, January 1, 2008; 10(5): 734 - 744. [Abstract] [Full Text] [PDF]

				M. E.L. Mauer, M. J.B. Taphoorn, A. Bottomley, C. Coens, F. Efficace, M. Sanson, A. A. Brandes, C. C.D. van der Rijt, H. J.J.A. Bernsen, M. Frenay, et al. Prognostic Value of Health-Related Quality-of-Life Data in Predicting Survival in Patients With Anaplastic Oligodendrogliomas, From a Phase III EORTC Brain Cancer Group Study J. Clin. Oncol., December 20, 2007; 25(36): 5731 - 5737. [Abstract] [Full Text] [PDF]

				I. Bosma, M. J. Vos, J. J. Heimans, M. J.B. Taphoorn, N. K. Aaronson, T. J. Postma, H. M. van der Ploeg, M. Muller, W. P. Vandertop, Ben. J. Slotman, et al. The course of neurocognitive functioning in high-grade glioma patients Neuro-oncol, January 1, 2007; 9(1): 53 - 62. [Abstract] [Full Text] [PDF]

				H. McCarter, W. Furlong, A. C. Whitton, D. Feeny, S. DePauw, A. R. Willan, and R. D. Barr Health Status Measurements at Diagnosis As Predictors of Survival Among Adults With Brain Tumors J. Clin. Oncol., August 1, 2006; 24(22): 3636 - 3643. [Abstract] [Full Text] [PDF]