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NEUROLOGY 2003;61:1796-1798
© 2003 American Academy of Neurology
Brief Communications

The prognostic value of cognitive functioning in the survival of patients with high-grade glioma

M. Klein, PhD, T.J. Postma, MD PhD, M.J.B. Taphoorn, MD PhD, N.K. Aaronson, PhD, W.P. Vandertop, MD PhD, M. Muller, MSc, H.M. van der Ploeg, PhD and J.J. Heimans, MD PhD

From the Departments of Medical Psychology (Drs. Klein and van der Ploeg), Neurology (Drs. Postma and Heimans), and Neurosurgery (Dr. Vandertop), VU University Medical Center, Amsterdam; Department of Neurology (Dr. Taphoorn), University Medical Center Utrecht; and Division of Psychosocial Research & Epidemiology (Drs. Aaronson and Muller), The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Address correspondence and reprint requests to Dr. M. Klein, VU University Medical Center, Department of Medical Psychology, Van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands; e-mail: m.klein{at}vumc.nl

The authors studied cognitive functioning as a potential predictor of survival in 68 newly diagnosed patients with high-grade glioma. In a combined Cox proportional hazards model, the influence of tumor, treatment, and patient characteristics, including cognitive functioning, was studied. Older age and higher tumor grade were associated with poorer survival. Although cognitive impairment was not found to be an independent prognostic factor for the entire sample, it was associated with significantly poorer survival among older patients with World Health Organization grade IV gliomas. Assessment of cognitive functioning in these patients may improve clinical decision making and thus quality of treatment.

Received June 12, 2003. Accepted in final form August 20, 2003.




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