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 Volume 61, Number 12, December 23, 2003
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NEUROLOGY 2003;61:1799-1801
© 2003 American Academy of Neurology
Brief Communications

Malformations of cortical development in neurofibromatosis type 1

P. Balestri, MD, R. Vivarelli, MD, S. Grosso, MD, L. Santori, MD, M. A. Farnetani, MD, P. Galluzzi, MD, G. P. Vatti, MD, F. Calabrese, MD and G. Morgese, MD

From the Departments of Pediatrics (Drs. Balestri, Vivarelli, Grosso, Santori, Farnetani, Calabrese, and Morgese) and Neurological Sciences (Dr. Vatti), University of Siena, Italy; and U.O. Neuroradiologia (Dr. Galluzzi), Azienda Ospedaliera Senese, Siena, Italy.

Address correspondence and reprint requests to Dr. Paolo Balestri, Department of Clinical Pediatrics, University of Siena, Viale M. Bracci, Le Scotte, 53100 Siena, Italy; e-mail: balestri{at}unisi.it

The authors report three patients with neurofibromatosis type 1 and different types of malformations of cortical development: Patient 1 had a possible transmantle cortical dysplasia involving the right temporoinsuloparieto-occipital areas; Patient 2 had a periventricular band of heterotopic gray matter with an overlying pachygyric cerebral cortex; and Patient 3 had a left perisylvian polymicrogyria. Because all of these lesions result from different pathogenetic mechanisms, neurofibromin may play a role during several stages of cortical development.

Received May 27, 2003. Accepted in final form July 29, 2003.




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