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NEUROLOGY 2003;61:1807-1810
© 2003 American Academy of Neurology
Brief Communications

Experience with immunomodulatory treatments in Rasmussen’s encephalitis

T. Granata, MD, L. Fusco, MD, G. Gobbi, MD, E. Freri, MD, F. Ragona, MD, G. Broggi, MD, R. Mantegazza, MD, L. Giordano, MD, F. Villani, MD, G. Capovilla, MD, F. Vigevano, MD, B. Dalla Bernardina, MD, R. Spreafico, MD and C. Antozzi, MD

From the Division of Child Neurology (Drs. Granata, Freri, and Ragona), Division of Neurosurgery (Dr. Broggi), Myopathology and Immunology Unit (Drs. Mantegazza and Antozzi), Division of Clinical Neurophysiology (Dr. Villani), and Division of Experimental Neurophysiology and Neuroanatomy (Dr. Spreafico), Istituto Nazionale Neurologico "C. Besta," Milan; Division of Neurology (Drs. Fusco and Vigevano), Ospedale Pediatrico "Bambino Gesù," Rome; Division of Neuropediatrics (Dr. Gobbi), Ospedale Maggiore Cà Pizzardi, Bologna; Division of Neuropediatrics (Dr. Giordano), Ospedali Civili, Brescia; Division of Neuropediatrics (Dr. Capovilla), Ospedale "C. Poma," Mantova; and Division of Neuropediatrics (Dr. Dalla Bernardina), Policlinico "Borgo Roma," Verona, Italy.

Address correspondence and reprint requests to Dr. Tiziana Granata, Division of Child Neurology, Istituto Nazionale Neurologico "C. Besta," Via Celoria 11, 20133 Milan, Italy; e-mail: granata{at}istituto-besta.it

The authors investigated immunomodulatory treatments in 15 patients with Rasmussen encephalitis (RE) (14 with childhood and one with adolescent onset RE). Positive time-limited responses were obtained in 11 patients using variable combinations of corticosteroids, apheresis, and high-dose IV immunoglobulins. Although surgical exclusion of the affected hemisphere is the only treatment that halts disease progression, immunomodulation can be considered when early surgery is not feasible, in late-onset patients with slower disease progression, and in the few cases of bilateral disease.

Received April 3, 2003. Accepted in final form July 31, 2003.

All authors form part of the Study Group on Rasmussen’s encephalitis of the Italian League Against Epilepsy.




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[Abstract] [Full Text] [PDF]

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R. T. Daniel, J.-G. Villemure, T. Granata, and C. Antozzi
Experience with immunomodulatory treatments in Rasmussen's encephalitis
Neurology, November 9, 2004; 63(9): 1761 - 1762.
[Full Text] [PDF]

Correspondence:

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Experience with immunomodulatory treatments in Rasmussen’s encephalitis
Roy T Daniel, et al.
Neurology Online, 19 Jun 2004 [Full text]
Reply to Daniel
Tiziana Granata, et al.
Neurology Online, 19 Jun 2004 [Full text]

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