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Neurology 2003;61:249-252
© 2003 American Academy of Neurology
Brief Communications

Prodromal and early epileptic seizures in acute stroke

Does higher serum cholesterol protect? G. Devuyst, MD, T. Karapanayiotides, MD, I. Hottinger, MD, G. Van Melle, MD and J. Bogousslavsky, MD

From the Service de Neurologie (Drs. Devuyst, Karapanayiotides, Hottinger, and Bogousslavsky), Centre Hospitalier Universitaire Vaudois, and Institute of Social and Preventive Medicine (Dr. Van Melle), Lausanne, Switzerland.

Address correspondence and reprint requests to Dr. G. Devuyst, Service de Neurologie, Centre Hospitalier Universitaire, Vaudois BH07/307, Rue du Bugnon 46, 1011 Lausanne, Switzerland; e-mail: Gerald.Devuyst{at}chuv.hospvd.ch

In a case-control study, patients (n = 43/3,628) presenting seizures <1 week before (n = 6), <=3 hours after (n = 26), and 3 to 24 hours after (n = 11) a first-ever stroke were studied. On multivariate analysis, they were characterized by lower levels of serum cholesterol (5.86 ± 0.51 vs 6.34 ± 0.58; p < 0.0001). Mortality and functional outcome at discharge were not influenced. Early poststroke seizures occur mainly during the critical 3-hour window for thrombolysis. Hypercholesterolemia appears to protect against seizures and cerebral ischemia.




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