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Neurology 2003;61:412-415
© 2003 American Academy of Neurology
Brief Communications

Cerebellar activation in opsoclonus

An fMRI study

C. Helmchen, MD, H. Rambold, MD, A. Sprenger, C. Erdmann and F. Binkofski, MD

From the Department of Neurology, University of Lübeck, Germany.

Address correspondence and reprint requests to Prof. Dr. Christoph Helmchen, Department of Neurology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany; e-mail: helmchen_ch{at}neuro.mu-luebeck.de

It is controversial whether opsoclonus is a cerebellar or brainstem disorder. Two patients whose opsoclonus largely disappeared on eye closure underwent fMRI. A comparison of these two states revealed neither vermal nor brainstem activation but rather a bilateral activation in the deep cerebellar nuclei in excess of what the authors found in healthy subjects. The results support a crucial role of the fastigial nucleus in opsoclonus.




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