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Neurology 2003;61:546-548
© 2003 American Academy of Neurology


Brief Communications

Risperidone-responsive segmental dystonia and pallidal deep brain stimulation

J. C. Wöhrle, MD, R. Weigel, MD, E. Grips, MD, C. Blahak, MD, H. H. Capelle, MD and J. K. Krauss, MD

From the Departments of Neurology (Drs. Wöhrle, Grips, and Blahak) and Neurosurgery (Drs. Weigel, Capelle, and Krauss),Universitätsklinikum, Mannheim, Germany.

Address correspondence and reprint requests to Dr. J.C. Wöhrle, Department of Neurology, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; e-mail: woehrle{at}neuro.ma.uni-heidelberg.de

A 67-year-old man with risperidone-responsive segmental dystonia underwent bilateral deep brain stimulation (DBS) of the globus pallidus internus. Prospectively, the authors assessed the Burke–Fahn–Marsden Dystonia Rating Scale in medication (M) and stimulation (S) "on"/"off" states. With DBS at 9 months, the score improved by 86% to 8.5 in M-"on"/S-"on" and 12.5 in M-"off"/S-"on." Studies of the effects of DBS and concomitant medication may be warranted in selected patients treated by DBS for dystonia.




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