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Neurology 2003;61:559-561
© 2003 American Academy of Neurology
Brief Communications

Effect of diet on exercise tolerance in carnitine palmitoyltransferase II deficiency

Mette C. Ørngreen, BS, Rasmus Ejstrup, BS and John Vissing, MD PhD

From the Copenhagen Muscle Research Center and Department of Neurology, National University Hospital, Rigshospitalet, Denmark.

Address correspondence and reprint requests to Dr. J. Vissing, Department of Neurology 2082, National University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; e-mail: vissing{at}rh.dk

It is generally believed that a diet high in carbohydrate improves exercise tolerance in patients with carnitine palmitoyltransferase II (CPT II) deficiency, but it has never been systematically investigated. The authors investigated the effect of a high- vs low-carbohydrate diet on exercise tolerance in four patients with CPT II, who cycled at a constant workload of 50% of VO2max. Exercise tolerance, assessed by exercise duration and perceived exertion, improved on the carbohydrate-rich diet.




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