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Neurology 2003;61:567-569
© 2003 American Academy of Neurology
Brief Communications

Response to systemic HIV viral load suppression correlates with psychomotor speed performance

N. Sacktor, MD, R. L. Skolasky, MA, P. M. Tarwater, PhD, J. C. McArthur, MB BS, MPH, O. A. Selnes, PhD, J. Becker, PhD, B. Cohen, MD, B. Visscher, MD PhD and E. N. Miller, PhD for the Multicenter AIDS Cohort Study (MACS)*

From the Department of Neurology (Drs. Sacktor, McArthur, and Selnes), Johns Hopkins University School of Medicine, and Department of Epidemiology (Drs. Tarwater and McArthur, R.L. Skolasky), Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; Neuropsychology Research Program (Dr. Becker), University of Pittsburgh Medical Center, PA; Department of Neurology (Dr. Cohen), Northwestern University, Chicago, IL; and Neuropsychiatric Institute (Dr. Miller) and School of Public Health (Dr. Visscher), University of California, Los Angeles.

Address correspondence and reprint requests to Dr. N. Sacktor, Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave., B-Bldg., Rm. 122, Baltimore, MD 21224; e-mail: sacktor{at}jhmi.edu

The authors evaluated the association of a virologic response to highly active antiretroviral therapy, or a subsequent rebound, with performance on two measures of psychomotor speed in HIV-positive subjects. Virologic suppression was associated with improved performance on measures of psychomotor speed, and virologic rebound was associated with psychomotor speed performance decline. Changes in plasma HIV viral load in HIV-positive individuals with cognitive slowing correlate with performance on tests of psychomotor speed.




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