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NEUROLOGY 2003;61:677-679
© 2003 American Academy of Neurology
Brief Communications

Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke

D. W.J. Dippel, MD, PhD, E. J. van Breda, MD, H. B. van der Worp, MD, PhD, H. M.A. van Gemert, MD, L. J. Kappelle, MD, PhD, A. Algra, MD, PhD and P. J. Koudstaal, MD, PhD

From the Department of Neurology (Drs. Dippel, van Breda, and Koudstaal), Erasmus Medical Center, Rotterdam; Department of Neurology (Drs. van der Worp, Kappelle, and Algra), University Medical Center, Utrecht; Department of Neurology (Dr. van Gemert), Meander Medisch Centrum, Amersfoort; and Julius Center for Health Sciences and Primary Care (Dr. Algra), Utrecht, the Netherlands.

Address correspondence and reprint requests to Dr. Diederik W.J. Dippel, Dept. of Neurology, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, the Netherlands; e-mail: d.dippel{at}erasmusmc.nl

The authors assessed the time of onset of the hypothermic effect of acetaminophen in 102 patients with acute ischemic stroke. These patients were randomized to treatment with either 1000 mg of acetaminophen (n = 52) or placebo (n = 50), given six times daily. Treatment with high-dose acetaminophen resulted in a 0.26 °C (95% CI 0.07 to 0.46 °C) lower mean body temperature than placebo treatment within 4 hours. This effect remained present throughout the next 20 hours. A large phase III trial seems warranted.

Received February 17, 2003. Accepted in final form April 19, 2003.




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