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Neurology 2003;61:683-685
© 2003 American Academy of Neurology
Brief Communications

Genetic variation of the APOE promoter and outcome after head injury

C. L. Lendon, PhD, J. M. Harris, BSc, A. L. Pritchard, BSc, J. A.R. Nicoll, MD, G. M. Teasdale, MD and G. Murray, PhD

From the Departments of Psychiatry and Neuroscience (Dr. Lendon, J.M. Harris and A.L. Pritchard), University of Birmingham, Public Health Sciences (Dr. Murray), Department of Community Health Sciences, University of Edinburgh Medical School, Division of Clinical Neurosciences (Dr. Nicoll), University of Southampton, and Department of Neurosurgery (Dr. Teasdale), University of Glasgow, Southern General Hospital, UK.

Address correspondence and reprint requests to Dr. C.L. Lendon, Departments of Psychiatry and Neuroscience, University of Birmingham, Birmingham, UK; e-mail: c.l.lendon{at}bham.ac.uk

The APOE-{epsilon}4 allele is associated with risk for Alzheimer’s disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors’ data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.




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