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Psychiatric adverse events during levetiracetam therapy

From the Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK.

Address correspondence and reprint requests to Dr. M.R. Trimble, Institute of Neurology, Queen Square, London WC1N 3BG, UK; e-mail: mtrimble{at}ion.ucl.ac.uk

The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilepticus, whereas lamotrigine co-therapy had a protective effect. PAE were not related to the titration schedule of LEV, and certain patients seem to be biologically more vulnerable.

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