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Neurology 2003;61:710-712
© 2003 American Academy of Neurology
Brief Communications

Retrospective diagnosis of congenital cytomegalovirus infection and cortical maldevelopment

C. Zucca, MD, S. Binda, PhD, R. Borgatti, MD, F. Triulzi, MD, L. Radice, MD, C. Buttè, MD, P. E. Barkhaus, MD and M. Barbi, MD

From the Neurophysiopathology Unit (Drs. Zucca and Radice), Neurorehabilitation Department (Dr. Borgatti), and Pediatrics Unit (Dr. Buttè), IRCCS "E. Medea," Bosisio Parini (LC), Italy; Institute of Virology (Drs. Binda and Barbi), University of Milan, Italy; Department of Radiology and Neuroradiology (Dr. Triulzi), Children Hospital "V. Buzzi" ICP, Milan, Italy; and Department of Neurology (Dr. Barkhaus), Medical College of Wisconsin, Milwaukee, WI.

Address correspondence and reprint requests to Dr. Claudio Zucca, Neurophysiopathology Unit, IRCCS "E. Medea," Via Don Luigi Monza, 20-23842 Bosisio Parini (LC), Italy; e-mail: zucca{at}bp.lnf.it

Congenital cytomegalovirus (CMV) infection can cause malformations of cortical development (MCD). It is difficult to establish CMV as a cause of MCD several months postpartum. This can now be done by detection of CMV DNA in dried blood spots (DBS test) on Guthrie cards. The authors used DBS tests to assess 10 patients with MCD of unknown cause. Four of the 10 patients were positive for CMV.




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Correspondence:

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Retrospective diagnosis of congenital cytomegalovirus infection and cortical maldevelopment
Kei Numazaki
Neurology Online, 5 Nov 2003 [Full text]
Reply to Numazaki
Claudio Zucca, et al.
Neurology Online, 11 Nov 2003 [Full text]

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