| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Psychiatry (Dr. Hershey), Neurology (Drs. Hershey, Revilla, Videen, and Perlmutter, and A.R. Wernle, L. McGee-Minnich, and J.V. Antenor), Neurological Surgery (Drs. Revilla and Dowling), Radiology (Drs. Videen and Perlmutter), and Anatomy and Neurobiology (Dr. Perlmutter), Washington University School of Medicine, St. Louis, MO; and Departments of Neurology, Neurobiology, and Pediatrics (Dr. Mink), University of Rochester Medical Center, Rochester, NY.
Address correspondence and reprint requests to Dr. J.S. Perlmutter, Campus Box 8111, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110; e-mail: joel{at}npg.wustl.edu
Objective: To assess whether subthalamic nuclei (STN) stimulation’s primary mechanism of action is to drive or inhibit output neurons.
Methods: Cerebral blood flow responses to STN stimulation were measured using PET in 13 patients with Parkinson disease. Patients were scanned with stimulators off and on (six scans each condition). Clinical ratings, EMG, and videotaping of movements were obtained at each scan. Scans with observable tremor or movement were eliminated from analysis. Brain regions where STN stimulation significantly altered blood flow were identified.
Results: STN stimulation increased blood flow in midbrain (including STN), globus pallidus, and thalamus, primarily on the left side, but reduced blood flow bilaterally in frontal, parietal, and temporal cortex.
Conclusions: These data suggest that STN stimulation increases firing of STN output neurons, which increases inhibition of thalamocortical projections, ultimately decreasing blood flow in cortical targets. STN stimulation appears to drive, rather than inhibit, STN output neurons.
This article has been cited by other articles:
|
|
 |
|
  D. M. Barch, T. S. Braver, C. S. Carter, R. A. Poldrack, and T. W. Robbins CNTRICS Final Task Selection: Executive Control Schizophr Bull, January 1, 2009; 35(1): 115 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Alberts, C. Voelcker-Rehage, K. Hallahan, M. Vitek, R. Bamzai, and J. L. Vitek Bilateral subthalamic stimulation impairs cognitive-motor performance in Parkinson's disease patients Brain, December 1, 2008; 131(12): 3348 - 3360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Xu, G. S. Russo, T. Hashimoto, J. Zhang, and J. L. Vitek Subthalamic Nucleus Stimulation Modulates Thalamic Neuronal Activity J. Neurosci., November 12, 2008; 28(46): 11916 - 11924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Dorval, G. S. Russo, T. Hashimoto, W. Xu, W. M. Grill, and J. L. Vitek Deep Brain Stimulation Reduces Neuronal Entropy in the MPTP-Primate Model of Parkinson's Disease J Neurophysiol, November 1, 2008; 100(5): 2807 - 2818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Karimi, N. Golchin, S. D. Tabbal, T. Hershey, T. O. Videen, J. Wu, J. W. M. Usche, F. J. Revilla, J. M. Hartlein, A. R. Wernle, et al. Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease Brain, October 1, 2008; 131(10): 2710 - 2719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Guo, J. E. Rubin, C. C. McIntyre, J. L. Vitek, and D. Terman Thalamocortical Relay Fidelity Varies Across Subthalamic Nucleus Deep Brain Stimulation Protocols in a Data-Driven Computational Model J Neurophysiol, March 1, 2008; 99(3): 1477 - 1492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Mallet, M. Schupbach, K. N'Diaye, P. Remy, E. Bardinet, V. Czernecki, M.-L. Welter, A. Pelissolo, M. Ruberg, Y. Agid, et al. Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior PNAS, June 19, 2007; 104(25): 10661 - 10666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Aron The Neural Basis of Inhibition in Cognitive Control Neuroscientist, June 1, 2007; 13(3): 214 - 228. [Abstract] [PDF]
|
|
|
|
|
|
J. Herzog, P. H. Weiss, A. Assmus, B. Wefer, C. Seif, P. M. Braun, H. Herzog, J. Volkmann, G. Deuschl, and G. R. Fink Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease Brain, December 1, 2006; 129(12): 3366 - 3375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Asanuma, C. Tang, Y. Ma, V. Dhawan, P. Mattis, C. Edwards, M. G. Kaplitt, A. Feigin, and D. Eidelberg Network modulation in the treatment of Parkinson's disease Brain, October 1, 2006; 129(10): 2667 - 2678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hershey and J. W. Mink Using functional neuroimaging to study the brain's response to deep brain stimulation Neurology, April 25, 2006; 66(8): 1142 - 1143. [Full Text] [PDF]
|
|
|
|
|
|
S. T. Grafton, R. S. Turner, M. Desmurget, R. Bakay, M. Delong, J. Vitek, and M. Crutcher Normalizing motor-related brain activity: Subthalamic nucleus stimulation in Parkinson disease Neurology, April 25, 2006; 66(8): 1192 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Chen and R. Lemon Subthalamic nucleus and gait disturbance: Interactions between basal ganglia and brainstem and spinal pathways? Neurology, October 12, 2004; 63(7): 1150 - 1151. [Full Text] [PDF]
|
|
|
|
|
|
R. Hanajima, P. Ashby, A. M. Lozano, A. E. Lang, and R. Chen Single Pulse Stimulation of the Human Subthalamic Nucleus Facilitates the Motor Cortex at Short Intervals J Neurophysiol, September 1, 2004; 92(3): 1937 - 1943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Sturman, D. E. Vaillancourt, L. V. Metman, R. A. E. Bakay, and D. M. Corcos Effects of subthalamic nucleus stimulation and medication on resting and postural tremor in Parkinson's disease Brain, September 1, 2004; 127(9): 2131 - 2143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Payoux, P. Remy, P. Damier, M. Miloudi, I. Loubinoux, B. Pidoux, V. Gaura, O. Rascol, Y. Samson, and Y. Agid Subthalamic Nucleus Stimulation Reduces Abnormal Motor Cortical Overactivity in Parkinson Disease Arch Neurol, August 1, 2004; 61(8): 1307 - 1313. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
