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Neurology 2003;61:851-853
© 2003 American Academy of Neurology
Brief Communications

Fatigue in MS is related to sympathetic vasomotor dysfunction

P. Flachenecker, MD, A. Rufer, I. Bihler, C. Hippel, MD, K. Reiners, MD, K.V. Toyka, MD and J. Kesselring, MD

From the Department of Neurology (Drs. Flachenecker, Reiners, and Toyka, and I. Bihler), Julius-Maximilians-Universität, Würzburg, Germany; and Department of Neurology (A. Rufer and Drs. Hippel and Kesselring), Rehabilitation Center Valens, Switzerland.

Address correspondence and reprint requests to Dr. Peter Flachenecker, Department of Neurology, University of Würzburg, Josef-Schneider-Str. 11, D-97080 Würzburg, Germany; e-mail: peter.flachenecker{at}surfeu.de

The authors studied standard autonomic function tests and measures of heart rate variability in 60 patients with multiple sclerosis (MS) and correlated results with the Fatigue Severity Scale and the Modified Fatigue Impact Scale. The authors found that autonomic responses correlated with fatigue resembling a hypoadrenergic orthostatic response, possibly due to a sympathetic vasomotor lesion with intact vagal heart control. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study.




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