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Neurology 2003;61:857-859
© 2003 American Academy of Neurology
Brief Communications

Lack of association of the potassium channel–associated peptide MiRP2-R83H variant with periodic paralysis

D. Sternberg, MD PhD, N. Tabti, MD PhD, E. Fournier, MD, B. Hainque, PhD and B. Fontaine, MD PhD

From the Federations of Biochemistry (Drs. Sternberg and B. Hainque), Physiology (Drs. Tabti and Fournier), and Neurology (Dr. Fontaine), Centre hospitalier universitaire Pitié-Salpêtrière (Assistance publique-hôpitaux de Paris et Université Paris VI), Faculty of Pharmaceutical Sciences (Dr. Hainque), Université Paris V, and INSERM U546 Research Unit (Drs. Tabti and Fontaine), Paris, France.

Address correspondence and reprint requests to Dr. B. Fontaine, INSERM U546, 105 boulevard de l’hôpital, 75013 Paris, France; e-mail: bertrand.fontaine{at}psl.ap-hop-paris.fr

A missense variant (R83H) of the gene (KCNE3) encoding a potassium channel–associated peptide, MinK-related peptide 2 (MiRP2), has been reported in periodic paralysis patients. In the current study, no difference in the frequency of the MiRP2-R83H variant between periodic paralysis patients and healthy individuals was found. Furthermore, there was no segregation of this gene variant with the disease. These observations weaken the proposal that MiRP2-R83H causes periodic paralysis.




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