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Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD

From the Department of Neurology (Drs. Eerola, Launes, and Tienari, and T. Peuralinna), Helsinki University Central Hospital and University of Helsinki, Biomedicum-Helsinki, Neuroscience Programme, Finland; Laboratory of Neurogenetics (D. Hernandez, C. Gulick, and J. Johnson, and Drs. Hague, Hardy, and Singleton), National Institute on Aging, NIH, Bethesda, MD; and Department of Neurology (Dr. Hellström), Seinäjoki Central Hospital, Finland.

Address correspondence and reprint requests to Dr. A.B. Singleton, Laboratory of Neurogenetics, National Institute on Aging, NIH, Building 10 Room 6C103, 9000 Rockville Pike, Bethesda, MD 20892; e-mail: singleta{at}mail.nih.gov

Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson’s disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic PD in a Finnish case-control series. This gene does not play a major role in the genetic predisposition to PD in this population.

Received January 29, 2003. Accepted in final form June 10, 2003.

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