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NEUROLOGY 2003;61:1008-1010
© 2003 American Academy of Neurology
Brief Communications

L-DOPA–induced excessive daytime sleepiness in PD

A placebo-controlled case with MSLT assessment

D. Garcia-Borreguero, MD, C. Schwarz, BSc, O. Larrosa, MD, Y. de la Llave, PhD and J. Garcia de Yébenes, MD

From the Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain.

Address correspondence and reprint requests to Dr. Diego Garcia-Borreguero, Sleep Disorders Unit, Department of Neurology, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Avda. Reyes Católicos 2, 28040 Madrid, Spain; e-mail: dgarciaborreguero{at}fjd.es

A 74-year-old patient with idiopathic Parkinson’s disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa. Overnight sleep studies and multiple sleep latency testing were carried out under double-blind administration of either L-dopa or placebo. Mean sleep latency with L-dopa was 7 minutes, in contrast to a normal value of 19 minutes, 25 seconds with placebo. The authors’ results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson’s disease.

Received October 28, 2002. Accepted in final form June 14, 2003.




This article has been cited by other articles:


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C. Serrano and D. Garcia-Borreguero
Fluctuations in cognition and alertness in Parkinson's disease and dementia
Neurology, October 26, 2004; 63(8_suppl_3): S31 - S34.
[Abstract] [Full Text]

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 NeurologyHome page
A. Romigi, M. G. Marciani, F. Placidi, and D. Garcia-Borreguero
L-dopa-induced excessive daytime sleepiness in PD: A placebo-controlled case with MSLT assessment
Neurology, April 27, 2004; 62(8): 1454 - 1455.
[Full Text] [PDF]

Correspondence:

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L-DOPA–induced excessive daytime sleepiness in PD: A placebo-controlled case with MSLT assessment
Andrea Romigi, et al.
Neurology Online, 11 Nov 2003 [Full text]
Reply to Romigi
Diego Garcia-Borreguero, MD
Neurology Online, 11 Nov 2003 [Full text]

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