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Does induction of plastic change in motor cortex improve leg function after stroke?

From the Department of Physiology (Drs. Ridding and Miles and J. Uy), University of Adelaide, and University Department of Medicine (Dr. Thompson), University of Adelaide and Royal Adelaide Hospital, and School of Physiotherapy (Dr. Hillier), University of South Australia, Adelaide.

Address correspondence and reprint requests to Dr. M.C. Ridding, Department of Physiology, University of Adelaide, Adelaide, South Australia 5005, Australia; e-mail: michael.ridding{at}adelaide.edu.au

Combined peripheral nerve and brain stimulation ("dual stimulation") induces changes in the excitability of normal motor cortex. The authors sought to establish whether dual stimulation would also induce motor cortex plasticity and associated functional improvements in nine stroke patients with chronic stable hemiparesis. Following 4 weeks of daily dual stimulation, improvements were seen in some neurophysiological and functional measures. This technique may offer therapeutic opportunities in some stroke patients.

Received September 13, 2002. Accepted in final form May 5, 2003.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the September 9 issue to find the title link for this article.

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