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From the Department of Public Health and Primary Health Care (Dr. Riise), Section of Occupational Medicine, University of Bergen; Faculty of Health and Social Sciences (Dr. Nortvedt), Bergen University College, Norway; and Departments of Nutrition and Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital (Dr. Ascherio), Boston, MA.
Address correspondence and reprint requests to Professor Trond Riise, Dept. of Public Health and Primary Health Care, University of Bergen, Ulriksdal 8c, N-5009 Bergen, Norway; e-mail: trond.riise{at}isf.uib.no
The authors determined the relationship between tobacco smoking and the risk of developing multiple sclerosis (MS) in a general population of 22,312 individuals living in Hordaland, Norway in 1997. A total of 87 individuals reported having developed MS. The risk of MS was higher among smokers than among never-smokers (rate ratio 1.81, 95% CI 1.1 to 2.9; p = 0.014). Studies on how smoking interacts with disease onset may contribute to determining the causal agents of this disease.
Received December 11, 2002. Accepted in final form May 22, 2003.
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Neurology 2003 61: 11-12.
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