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NEUROLOGY 2003;61:1134-1135
© 2003 American Academy of Neurology
Brief Communications

Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction

D.F. Tang-Wai, MD CM, K.A. Josephs, MST MD, B.F. Boeve, MD, D.W. Dickson, MD, J.E. Parisi, MD and R.C. Petersen, PhD MD

From the Departments of Neurology (Drs. Tang-Wai, Josephs, Boeve, and Petersen) and Laboratory Medicine and Pathology (Dr. Parisi), Mayo Clinic, Rochester, MN; and Neuropathology Laboratory (Dr. Dickson), Mayo Clinic, Jacksonville, FL.

Address correspondence and reprint requests to Dr. Bradley F. Boeve, Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, MN 55905; e-mail: bboeve{at}mayo.edu

Corticobasal degeneration (CBD) typically manifests as progressive asymmetric rigidity and apraxia, although other non-motor presentations have been reported. We report two patients with pathologically diagnosed CBD who presented with prominent visuospatial dysfunction. The pathological changes were maximal in the visual association cortices, but absent in 31 cases of pathologically proven CBD with more typical antemortem features. Underlying CBD should be considered in the differential diagnosis of patients with findings reflecting posterior cerebral dysfunction.

Received April 15, 2003. Accepted in final form June 16, 2003.




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