Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mosconi, L.
Right arrow Articles by Pupi, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mosconi, L.
Right arrow Articles by Pupi, A.
Related Collections
Right arrow MRS
Right arrow Alzheimer's disease
Right arrow All Genetics
NEUROLOGY 2003;61:1138-1140
© 2003 American Academy of Neurology
Brief Communications

Brain metabolic differences between sporadic and familial Alzheimer’s disease

L. Mosconi, MD, S. Sorbi, MD, B. Nacmias, PhD, M.T.R. De Cristofaro, MD, M. Fayyaz, MD, E. Cellini, PhD, S. Bagnoli, PhD, L. Bracco, MD, K. Herholz, MD and A. Pupi, MD

From the Department of Clinical Pathophysiology, Nuclear Medicine Unit (Drs. Mosconi, De Cristofaro, Fayyaz, and Pupi), and Department of Neurological and Psychiatric Sciences (Drs. Sorbi, Nacmias, Cellini, Bagnoli, and Bracco), University of Florence, Italy; and University of Cologne (Dr. Herholz), Neurological Clinic and Max-Planck-Institute for Neurological Research, Köln, Germany.

Address correspondence and reprint requests to Dr. Prof. Alberto Pupi, Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, viale Morgagni 85, 50134 Florence, Italy; e-mail: a.pupi{at}dfc.unifi.it

This FDG-PET study with SPM99 compared 46 patients with sporadic Alzheimer disease (SAD) to 40 patients with familial AD (FAD) and to 35 matched controls. AD groups had equivalent metabolic (METglu) reductions in several cortical and limbic areas with respect to the controls. Patients with FAD showed decreased METglu in the posterior cingulate, parahippocampal, and occipital cortex as compared to the patients with SAD (p < 0.001). Genetic factors lead to phenotypic differences in AD.

Received February 14, 2003. Accepted in final form June 23, 2003.




This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
L Mosconi, K Herholz, I Prohovnik, B Nacmias, M T R De Cristofaro, M Fayyaz, L Bracco, S Sorbi, and A Pupi
Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve
J. Neurol. Neurosurg. Psychiatry, January 1, 2005; 76(1): 15 - 23.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by AAN Enterprises, Inc.