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NEUROLOGY 2003;61:1256-1259
© 2003 American Academy of Neurology
Brief Communications

Distinct cytokine profile in SIDS brain

A common denominator in a multifactorial syndrome?

Hazim Kadhim, MD PhD, André Kahn, MD PhD and Guillaume Sébire, MD PhD

From the Laboratoire de Neurologie du Développement (Drs. Kadhim and Sébire), Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCL), Brussels; Unité de Neuropathologie, Service d’Anatomopathologie, CHU Brugmann-HUDERF (Dr. Kadhim), and Service de Pédiatrie, Hôpital Universitaire des Enfants Reine Fabiola HUDERF (Drs. Kadhim and Kahn), Université Libre de Bruxelles (ULB), Belgium; and Service de Neurologie Pédiatrique (Dr. Sébire), CHU Fleurimont, Université de Sherbrooke, Canada.

Address correspondence and reprint requests to Dr. Hazim Kadhim, Laboratoire de Neurologie du Développement (NEPE), Université Catholique de Louvain (UCL), Avenue Mounier 52, Tour Vésale, NEPE, 1200 Brussels, Belgium; e-mail: Hazim.Kadhim{at}nepe.ucl.ac.be

Cytokines modify neuronal function. Dysfunction in vital centers is reported in sudden infant death syndrome (SIDS). The authors detected high neuronal interleukin (IL)-1ß immunoreactivity in the arcuate and dorsal vagal nuclei in SIDS. This IL-1 overexpression might contribute to molecular interactions in brainstem neurovegetative centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.

Received November 4, 2002. Accepted in final form July 22, 2003.

See also page 1170




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