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NEUROLOGY 2003;61:1282-1284
© 2003 American Academy of Neurology
Brief Communications

A randomized controlled trial of recombinant interferon-beta 1a in Guillain-Barré syndrome

J. Pritchard, BM BCh, I. A. Gray, MIScT, Z. R. Idrissova, PhD, B. R.F. Lecky, MD, I. J. Sutton, MB ChB, A. V. Swan, PhD, H. J. Willison, PhD, J. B. Winer, MD and R. A.C. Hughes, MD

From the Department of Clinical Neurosciences (J. Pritchard and I.A. Gray, and Drs. Idrissova, Swan, and Hughes), Guy’s, King’s & St. Thomas’ School of Medicine, London; The Walton Centre for Neurology and Neurosurgery (Dr. Lecky), Liverpool; the Department of Neurology (I.J. Sutton and Dr. Winer), Queen Elizabeth Hospital, Birmingham; and Institute of Neurological Sciences (Dr. Willison), Southern General Hospital, University of Glasgow, UK.

Address correspondence and reprint requests to Professor R.A.C. Hughes, Department of Clinical Neurosciences, Guy’s, King’s & St. Thomas’ School of Medicine, Hodgkin Building, Guy’s Hospital, London SE1 1UL, UK; e-mail: Richard.a.Hughes{at}kcl.ac.uk

The authors recruited 19 nonambulant patients with Guillain-Barré syndrome into a pilot, double-blind, randomized, placebo-controlled safety trial of interferon beta 1a (IFNß-1a) (Rebif). Participants received IFNß-1a or placebo subcutaneously three times weekly, 22 µg for the first week and then 44 µg for up to 24 weeks, in addition to IV immunoglobulin (IVIg). IFNß did not have any unexpected interaction with IVIg and there was no significant difference in rate of improvement.

Received May 20, 2003. Accepted in final form July 18, 2003.




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