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NEUROLOGY 2004;62:122-124
© 2004 American Academy of Neurology
Brief Communications

Pilot trial of 1-octanol in essential tremor

K. O. Bushara, MD, S. R. Goldstein, MD, G. J. Grimes, Jr., PharmD, A. H. Burstein, PharmD and M. Hallett, MD

From the Human Motor Control Section (Drs. Bushara, Goldstein, and Hallett), Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, and Pharmacy Department (Drs. Grimes and Burstein), Magnuson Clinical Center, NIH, Bethesda, MD; and Neurology Service (Dr. Bushara), Minneapolis Veterans Affairs Medical Center, Minneapolis, MN.

Address correspondence and reprint requests to Dr. K. Bushara, Neurology Service (127), Minneapolis Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417; e-mail: busha001{at}umn.edu

1-Octanol (an 8-C alcohol currently used as a food-flavoring agent) is known to inhibit tremor in essential tremor (ET) animal models at a much lower dose than ethyl alcohol. The authors conducted a randomized, placebo-controlled pilot trial of a single oral dose of 1 mg/kg of 1-octanol in 12 patients with ET. No significant side effects or signs of intoxication were observed. 1-Octanol significantly decreased tremor amplitude for up to 90 minutes. The results suggest 1-octanol as a well-tolerated and safe potential treatment for ET. Further trials are warranted.

Received January 13, 2003. Accepted in final form September 16, 2003.




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