Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tan, E. K.
Right arrow Articles by Yap, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tan, E. K.
Right arrow Articles by Yap, E.
NEUROLOGY 2004;62:128-131
© 2004 American Academy of Neurology
Brief Communications

Alpha-synuclein haplotypes implicated in risk of Parkinson’s disease

E. K. Tan, MD, A. Chai, BSc, Y. Y. Teo, MSc, Y. Zhao, MD PhD, C. Tan, BSc, H. Shen, PhD, V. R. Chandran, PhD, M. L. Teoh, MD, Y. Yih, MD, R. Pavanni, MD, M. C. Wong, FRCP, K. Puvan, FRCP, Y. L. Lo, MD and E. Yap, MD

From the Departments of Neurology (Drs. E.K. Tan, Shen, Chandran, Pavanni, Wong, Puvan, and Lo, and A. Chai and C. Tan), Clinical Research (Dr. Zhao), and Health Screening (Drs. Teoh and Yih), Singapore General Hospital; National Neuroscience Institute (Drs. E.K. Tan, Pavanni, Wong, Puvan, and Lo); SingHealth Research (Dr. E.K. Tan); and Defence Medical Research Institute (Dr. Yap), Singapore.

Address correspondence and reprint requests to Dr. Eng-King Tan, Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608; e-mail: gnrtek{at}sgh.com.sg

The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson’s disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four-loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD.

Received June 17, 2003. Accepted in final form September 11, 2003.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the January 13 issue to find the title link for this article.




This article has been cited by other articles:


Home page
 FASEB J.Home page
J. Fuchs, A. Tichopad, Y. Golub, M. Munz, K. J. Schweitzer, B. Wolf, D. Berg, J. C. Mueller, and T. Gasser
Genetic variability in the SNCA gene influences {alpha}-synuclein levels in the blood and brain
FASEB J, May 1, 2008; 22(5): 1327 - 1334.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. Winkler, J. Hagenah, S. Lincoln, M. Heckman, K. Haugarvoll, K. Lohmann-Hedrich, V. Kostic, M. Farrer, and C. Klein
{alpha}-Synuclein and Parkinson disease susceptibility
Neurology, October 30, 2007; 69(18): 1745 - 1750.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
R. L. Clough and L. Stefanis
A novel pathway for transcriptional regulation of {alpha}-synuclein
FASEB J, February 1, 2007; 21(2): 596 - 607.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. M. Maraganore, M. de Andrade, A. Elbaz, M. J. Farrer, J. P. Ioannidis, R. Kruger, W. A. Rocca, N. K. Schneider, T. G. Lesnick, S. J. Lincoln, et al.
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.
JAMA, August 9, 2006; 296(6): 661 - 670.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
T Ozawa, D G Healy, P M Abou-Sleiman, K R Ahmadi, N Quinn, A J Lees, K Shaw, U Wullner, J Berciano, J C Moller, et al.
The {alpha}-synuclein gene in multiple system atrophy
J. Neurol. Neurosurg. Psychiatry, April 1, 2006; 77(4): 464 - 467.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
E.-K. Tan, D. K.-Y. Chan, P.-W. Ng, J. Woo, Y. Y. Teo, K. Tang, L.-P. Wong, S. S. Chong, C. Tan, H. Shen, et al.
Effect of MDR1 Haplotype on Risk of Parkinson Disease
Arch Neurol, March 1, 2005; 62(3): 460 - 464.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
J. L. Cummings
Dementia with Lewy Bodies: Molecular Pathogenesis and Implications for Classification
J Geriatr Psychiatry Neurol, September 1, 2004; 17(3): 112 - 119.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by AAN Enterprises, Inc.