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Antigliadin antibodies in Huntington’s disease

From the Department of Neurology (Drs. Bushara, Nance, and Gomez), University of Minnesota; Neurology Service (Dr. Bushara), Minneapolis VA Medical Center; and Department of Neurology (Dr. Nance), Hennepin County Medical Center, Minneapolis, MN.

Address correspondence and reprint requests to Dr. Khalafalla Bushara, Minneapolis VA Medical Center (127), One Veterans Drive, Minneapolis, MN 55417; e-mail: busha001{at}umn.edu

The relevance of gluten sensitivity in sporadic and hereditary ataxia pathogenesis is unclear. The authors found high antigliadin antibody titers in 23 of 52 (44%) patients with Huntington’s disease (HD), suggesting a previously unrecognized association between HD and gluten sensitivity. The results further question "gluten ataxia" as a distinct disease entity and raise the possibility that antigliadin antibodies in ataxia and other neurodegenerative diseases may be an epiphenomenon, the mechanisms of which remain to be investigated.

Received May 19, 2003. Accepted in final form September 8, 2003.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the January 13 issue to find the title link for this article.

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