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Association between the tumor necrosis factor- -308 G/A gene polymorphism and migraine

From Neurology III Headache Center (Drs. Rainero, Valfrè, Rivoiro, Savi, and Pinessi), Department of Neuroscience, University of Torino, Neuroimmunology Unit (Drs. Grimaldi and Salani), Department of Neuroscience, IRCCS San Raffaele, Milano, and Department of Neuroscience (Dr. Grimaldi), AUSL n. 2, Caltanisetta, Italy.

Address correspondence and reprint requests to Dr. I. Rainero, Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco, 15-10126 Torino, Italy; e-mail: irainero{at}molinette.piemonte.it

In a group of 299 migraine patients and 306 control subjects, the association of the -308 G/A polymorphism in the tumor necrosis factor- gene (TNF) with the occurrence and clinical characteristics of migraine was tested. Homozygosity for the G allele was associated with an increased risk of migraine (odds ratio [OR] = 2.85, p < 0.001). When the patients were divided into subgroups, the association was confirmed in patients affected by migraine without aura (OR = 3.30, p < 0.001) but not in migraine with aura. These data suggest that the TNF gene or a linked locus significantly modulates the risk for migraine.

Received June 4, 2003. Accepted in final form September 11, 2003.