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NEUROLOGY 2004;62:144-146
© 2004 American Academy of Neurology
Brief Communications

Absence of IgG1 response in the cerebrospinal fluid of relapsing neuromyelitis optica

I. Nakashima, MD, K. Fujihara, MD, J. Fujimori, MD, K. Narikawa, MD, T. Misu, MD and Y. Itoyama, MD

From the Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.

Address correspondence and reprint requests to Dr. Ichiro Nakashima, Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan; e-mail: nakashima{at}em.neurol.med.tohoku.ac.jp

The authors studied immunoglobulin (Ig) G subclasses in the CSF and sera of patients with relapsing neuromyelitis optica (RNMO) and typical multiple sclerosis (MS). Although the total IgG concentrations were elevated in the CSF of patients with RNMO and MS, IgG1% and IgG1 index were significantly elevated only in patients with MS. The absence of the CSF IgG1 responses in the patients with RNMO may suggest less Th1 immunity and may also explain the rarity of oligoclonal IgG bands in patients with this disease.

Received June 20, 2003. Accepted in final form August 27, 2003.




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