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NEUROLOGY 2004;62:1804-1809
© 2004 American Academy of Neurology

Autonomic dysfunction in dementia with Lewy bodies

P. Thaisetthawatkul, MD, B. F. Boeve, MD, E. E. Benarroch, MD DSc, P. Sandroni, MD PhD, T. J. Ferman, PhD, R. Petersen, MD PhD and P. A. Low, MD

From the Department of Neurology (Drs. Thaisetthawatkul, Benarroch, Sandroni, and Low), Peripheral Nerve and Autonomic Disorders Center, and Department of Neurology (Drs. Boeve and Petersen), Division of Behavioral Neurology, Mayo Clinic, Rochester, MN; and Department of Psychiatry and Psychology (Dr. Ferman), Mayo Clinic, Jacksonville, FL.

Address correspondence and reprint requests to Dr. Phillip A. Low, Mayo Clinic, 200 First Street SW, Rochester, MN 55905; e-mail: low{at}mayo.edu

Objective: To assess autonomic function in patients with dementia with Lewy bodies (DLB).

Methods: The authors compared data from 20 DLB patients evaluated from 1995 to 2000 to 20 age-matched multiple system atrophy (MSA) and Parkinson disease (PD) patients evaluated from 1999 to 2002. Analysis of variance, Fisher exact test, and Student t-test were applied to compare disease characteristics, autonomic symptoms, and function tests on the Composite Autonomic Scoring Scale (CASS) and Thermoregulatory Sweat Test (TST).

Results: In DLB, mean age at onset of autonomic symptoms was 70.3 ± 8.9 years. Orthostatic symptoms were common and orthostatic hypotension occurred in 10/20 DLB, 17/20 MSA, and 1/20 PD patients (p = 0.023, 0.003). CASS-sudomotor for DLB, MSA, and PD were 1.6 ± 1.2, 2.5 ± 0.7, and 0.9 ± 0.8 (p < 0.00001). CASS-cardiovagal were 1.4 ± 0.9, 2.1 ± 0.8, and 0.7 ± 0.6 (p < 0.00001). CASS-adrenergic function were 2.4 ± 1.2, 3.5 ± 0.9, and 0.5 ± 0.6 (p < 0.00001). Total CASS were 5.2 ± 2.0, 8.1 ± 1.3, and 2.2 ± 1.2 (p < 0.00001). The most common pattern of TST in DLB was distal anhidrosis. Mean duration of follow-up was 3.0 ± 1.8 years. Six patients needed medication to maintain blood pressure and five had good response.

Conclusions: Autonomic dysfunction is frequent in dementia with Lewy bodies and the severity is intermediate between that of multiple system atrophy and Parkinson disease.

Received July 22, 2003. Accepted in final form January 16, 2004.




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