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 Volume 62, Number 10, May 25, 2004
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NEUROLOGY 2004;62:1818-1821
© 2004 American Academy of Neurology

Electrocardiographic Q-waves as a predictor of mortality in patients with cerebral infarction

M. Tanaka, MD, Y. Nakayama, MD, Y. Maeda, MD, T. Nishioka, MD, M. Shirakawa, MD and K. Tsumura, MD

From the Departments of Cardiology (Drs. Tanaka and Nakayama) and Neurosurgery (Drs. Maeda, Nishioka, and Shirakawa), Ishikiriseiki Hospital; and Department of Physiology (Dr. Tanaka) and Center for General Medicine (Dr. Tsumura), Osaka City University Graduate School of Medicine, Osaka, Japan.

Address correspondence and reprint requests to Dr. Masaaki Tanaka, Department of Physiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545–8585, Japan; e-mail: masa-t{at}msic.med.osaka-cu.ac.jp

Objective: To determine whether abnormal EKG findings could be predictive factors for death after a stroke event.

Methods: Patients with acute cerebral infarction who were 35 to 98 years old during April 1996 through November 2000 were analyzed (n = 216). A standard 12-lead EKG was recorded for each patient after acute cerebral infarction. The authors prospectively investigated the association between abnormal EKG findings and the risk for death after stroke over a 1-year period.

Results: Using multivariate Cox proportional hazards models, the authors found age (hazard ratio of mortality per year 1.10, 95% CI 1.06 to 1.15, p < 0.001), sex (female; hazard ratio of mortality 3.42, 95% CI 1.43 to 8.19, p = 0.006), and the presence of Q-waves in more than two leads (hazard ratio of mortality 2.75, 95% CI 1.23 to 6.14, p = 0.013) were independently associated with death after stroke.

Conclusion: The presence of Q-waves in more than two leads could be a predictive factor for death after acute cerebral infarction.

Received August 22, 2003. Accepted in final form January 27, 2004.






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