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NEUROLOGY 2004;62:1854-1856
© 2004 American Academy of Neurology
Brief Communications

Intravenous r-TPA in vertebrobasilar acute infarcts

A. Montavont, MD, N. Nighoghossian, MD, L. Derex, MD, M. Hermier, MD, J. Honnorat, MD, F. Philippeau, MD, M. Belo, MD, F. Turjman, MD, P. Adeleine, MD, J. C. Froment, MD and P. Trouillas, MD PhD

From the Cerebrovascular Disease Center (Drs. Montavont, Nighoghossian, Derex, Honnorat, Philippeau, Belo, and Trouillas) and Department of Radiology (Drs. Hermier, Turjman, and Froment), Creatis UMR 5515 (Dr. Adeleine), CNRS, and Biostatistical Unit, HCL, France.

Address correspondence and reprint requests to Dr. N. Nighoghossian, Cerebrovascular Unit, Hopital Neurologique 59, bd Pinel 69394, Lyon Cedex 03, France; e-mail: norbert.nighoghossian{at}chu-lyon.fr

Presented are the clinical data of 18 consecutive patients who were treated by IV recombinant tissue plasminogen activator (r-TPA) for suspected vertebrobasilar (VB) acute ischemia within 7 hours. The mean delay for treatment was 5 ± 3.6 hours. Mean baseline NIH Stroke Scale score was 17 ± 4. At 3 months, 10 patients were independent (modified Rankin Scale [mRS] score = 0 to 2), whereas 8 patients showed a poor outcome (mRs = 3 to 6). IV r-TPA in VB ischemia in a 7-hour window may be safe and efficient.

Received September 16, 2003. Accepted in final form January 16, 2004.




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