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The metabolic topography of posthypoxic myoclonus

Steven J. Frucht, MD, Maja Trot, MD, Yilong Ma, PhD and David Eidelberg, MD

From the Department of Neurology (Dr. Frucht), Columbia-Presbyterian Medical Center, New York, NY; The Functional Brain Imaging Laboratory (Drs. Trot, Ma, and Eidelberg), North Shore University Hospital, Manhasset, NY; and Department of Neurology (Dr. Trot), Division of Neurology, University Medical Center Ljubljana, Slovenia.

Address correspondence and reprint requests to Dr. Steven Frucht, The Neurologic Institute, 710 West 168th Street, New York, NY 10032; e-mail: sf216{at}columbia.edu

Posthypoxic myoclonus (PHM) is a syndrome of action and intention myoclonus that occurs in some patients who survive a cardiac arrest. Using PET and statistical parametric mapping, the authors observed a significant bilateral increase in glucose metabolism in the ventrolateral thalamus and pontine tegmentum in patients relative to controls. Interventions such as deep brain stimulation that interrupt networks that involve these structures may be useful in patients with severe PHM.

Received October 23, 2003. Accepted in final form January 13, 2004.

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